To use Ruby in a Node.js environment, install the @ruby/4.0-wasm-wasi and @ruby/wasm-wasi npm packages. You can then instantiate a Ruby VM by reading the .wasm binary, compiling it, and using DefaultRubyVM from @ruby/wasm-wasi/dist/node.
import fs from "fs/promises";
import { DefaultRubyVM } from "@ruby/wasm-wasi/dist/node";
const binary = await fs.readFile("./node_modules/@ruby/4.0-wasm-wasi/dist/ruby.wasm");
const module = await WebAssembly.compile(binary);
const { vm } = await DefaultRubyVM(module);
vm.eval(`puts "hello world"`);